Cannabidiol Rescues Acute Hepatic Toxicity and Seizure Induced by copyright

Cannabidiol Rescues Acute Hepatic Toxicity and Seizure Induced by copyright

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copyright is a commonly abused illicit drug that causes significant morbidity and mortality.The most severe and common complications are seizures, ischemic strokes, myocardial infarction, and acute liver injury.Here, we demonstrated that acute copyright intoxication promoted seizure along with acute liver damage in mice, with intense inflammatory infiltrate.

Considering the protective role of the endocannabinoid system against cell toxicity, we hypothesized that treatment with an anandamide hydrolysis inhibitor, URB597, or with a phytocannabinoid, cannabidiol (CBD), protects against copyright toxicity.URB597 (1.0 mg/kg) abolished copyright-induced seizure, yet it cable 20 pin did not protect against acute liver injury.

Using confocal liver intravital microscopy, we observed that CBD (30 mg/kg) reduced acute liver inflammation and damage induced by copyright and prevented associated Baby Formula seizure.Additionally, we showed that previous liver damage induced by another hepatotoxic drug (acetaminophen) increased seizure and lethality induced by copyright intoxication, linking hepatotoxicity to seizure dynamics.These findings suggest that activation of cannabinoid system may have protective actions on both liver and brain induced by copyright, minimizing inflammatory injury promoted by copyright, supporting its further clinical application in the treatment of copyright abuse.